We stopped reducing the disease to a single target and the drug as a silver bullet?
We define the diseases as deviation from equilibrium of multiple biological processes – the homeostasis – at the cellular, tissue and the systems level that maintains our health?
We can learn from mother Nature how it “fixes” the homeostasis in other species and use this knowledge to develop entirely new class of drugs?
Aveta Biomics is pioneering a new way to harness the power of evolutionary biology to create therapeutics for cancer, infectious diseases and diseases resulting from chronic inflammation. Our platform, based on novel insights into the relational synergy among the active molecules and pleiotropic modes of action, aims to create first-in-class drugs that provide a durable clinical response.
Parag G. Mehta, PhD, Co-founder and CEO is a serial entrepreneur with a track record of commercializing novel chemistry based innovations. He has strong background in biotechnology, organic, macromolecular and biochemistry and material science. His experience encompasses product R&D, global business development, manufacturing and capitalization of companies through public and private financing. He received his PhD in Chemistry from Rensselaer Polytechnic Institute, Troy, NY and MSc in Chemistry from Indian Institute of Technology, Mumbai, India.
Luis Z Avila, PhD, Vice President, Drug Discovery & Development, brings to Aveta Biomics more than 20 years of industrial experience spanning early startup (Focal, Inc) through biotech (Genzyme) and most recently as Distinguished Scientific Fellow at a multinational pharmaceutical company (Sanofi). He has successfully guided several product concepts through various phases of discovery, optimization, product development and CMC for clinical evaluation and/or product launch (either internally and with external company collaborators). He obtained his PhD in Bioorganic Chemistry from Stanford University and was a Postdoctoral Fellow at Harvard University (Department of Chemistry and Chemical Biology). He holds more than twenty issued US patents and coauthored more than twenty scientific articles and book chapters on topics including bioorganic chemistry, biomaterials, drug delivery, bioconjugation and biologic+synthetic hybrid products.
Eugene I. Shakhnovich, PhD, Scientific Advisor is a Professor of Chemistry and Chemical Biology at Harvard University. He is one of the leading researchers in the areas of protein folding and has carried out crucial work tying the physical chemistry of protein with the evolutionary biology. His laboratory has made fundamental contributions to understanding of the mechanisms of drug resistance by studying the mutational fitness of an organismal evolution using the biophysical principles. He is the author of more than 200 publications, serves on the editorial boards of several major journals and is a recipient of several awards and fellowships. Prof. Shakhnovich is also an entrepreneur who co-founded Vitae Pharmaceuticals (NASDAQ:VTAE) which was recently acquired by Allergan for $639 million.
Daniel L. Hartl, PhD, Scientific Advisor is Higgins Professor of Biology and former Chair of the Department of Organismic and Evolutionary Biology at Harvard University. His laboratory studies genetics, genomics and molecular evolution. His seminal contributions to experimental evolutionary genetics have far-reaching impact on understanding the development of resistance to drugs in human diseases. An elected member of the National Academy of Sciences, USA, the American Academy of Arts and Sciences, and the National Academy of Sciences of India, Prof. Hartl has been honored with the Samuel Weiner Outstanding Scholar Award and the Medal of the Stazione Zoologica Anton Dohrn. He is a Past President of the Genetics Society of America and the Society for Molecular Biology and Evolution and has served on the National Institutes of Health Genetics Study Section, Genetic Basis of Disease Review Committee, and on the Editorial Boards of Genetics, Annual Review of Genetics and, Molecular Biology and Evolution. He has authored or coauthored more than 400 scientific articles and 20 books including Genetics: Analysis of Genes and Genomes, Essential Genetics: A Genomics Perspective, Principles of Population Genetics and Primer of Population Genetics.
Bharat Aggarwal, PhD, Scientific Advisor, Director of Inflammation Research Institute in San Diego, CA and a just retired Chaired professor and chief of the Cytokine Research at M.D. Anderson Cancer Center, Univ. of Texas is world’s foremost researcher in areas of inflammation and is well-known for his ground-breaking work on use of natural products to combat many diseases. Earlier at Genentech his team characterized TNF-alpha and TNF-beta, key cytokines involved in cancer. He has made seminal contributions in inflammation biology, role of cytokines in tumor cell growth and mechanism of tumor cell resistance. He has authored more than 500 original articles in peer-reviewed journals, edited 12 books, is co-inventor of 33 patents, and has Scholar h-index of 157 with 89,500 citations.