APG-157 development programs

A patient speaking with his physician

Aveta is advancing APG-157 across clinical and preclinical programs in cancers where reprogramming the tumor immune microenvironment may offer a new therapeutic approach.

Program
Indication
PreclinicalPhase 1Phase 2Phase 3
Study
APG-157
Newly Diagnosed Locally Advanced
Head and Neck Cancer
FDA Fast Track DesignationFDA Orphan Drug Designation
Phase 3
APG-157 +
Bevacizumab
Recurrent High Grade Glioma
Phase 1b/2a
APG-157
Oral Dysplasia
Phase 2
APG-126
Triple Negative Breast Cancer
Preclinical
APG-126
Diffuse Intrinsic Pontine Glioma (DIPG)
Preclinical

Development stage reflects the most advanced study for each indication.

Head & Neck Cancer

950,000

new diagnoses worldwide each year


400,000

deaths worldwide each year

High Grade Glioma

300,000–335,000

new diagnoses worldwide each year


220,000–250,000

deaths worldwide each year

Oral Dysplasia

An opportunity to intervene before invasive cancer develops.


Oral dysplasia is a precancerous condition that can progress to invasive oral cancer.